Bax-responsive genes for drug target identification in yeast...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/40 (2006.01) C07K 14/47 (2006.01) C07K 16/14 (2006.01) C12N 9/02 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2432364

The invention describes the use of nucleic acids and polypeptides which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases associated with yeast or fungi or for the treatment of prolifeative disorders or for preventing apoptosis in certain diseases. Methods are provided to identify compounds which selectively modulate the expression or functionality of said polypeptides in the same or a parallel pathway. Also provided are compounds as well as pharmaceutical compositions, medicaments and vaccines. The invention also comprises new nucleic acid sequences, probes and primers derived thereof, expression vectors and host cells transformed with said vectors, polypeptides and antibodies raised against said polypeptides.

L'invention concerne l'utilisation d'acides nucléiques et de polypeptides faisant partie d'un mécanisme qui provoque finalement la mort programmée des cellules de levure ou de champignons, à des fins de préparation d'un médicament destiné à traiter des maladies associées à la levure ou les champignons ou pour traiter les troubles prolifératifs, ou encore dans la prévention de l'apoptose lors de certaines maladies. L'invention concerne aussi des procédés pour identifier des composés qui modulent de façon sélective l'expression ou les fonctionnalités de ces polypeptides dans le même mécanisme ou un mécanisme parallèle. L'invention concerne également des composés et des compositions pharmaceutiques, des médicaments et des vaccins, de même que de nouvelles séquences d'acides nucléiques, des sondes et des amorces dérivées, des vecteurs d'expression et des cellules hôtes transformées avec ces vecteurs, des polypeptides et des anticorps cultivés contre ces polypeptides.

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