C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/10 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/54 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2460128
The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
La présente invention concerne des méthodes d'identification de composés modulant l'apoptose, directement ou indirectement, par des changements de l'expression du gène bbc3 ou d'un gène rapporteur, ou par des changements du caractère apoptotique d'une cellule. La présente invention concerne également des méthodes d'identification de composés modulant l'expression du gène bbc3 et une méthode d'identification de composés interagissant avec un promoteur du gène bbc3. La présente invention concerne en outre une méthode de modulation de l'apoptose dans une cellule, une méthode de modulation de l'expression du gène bbc3 dans une cellule, un procédé de fabrication d'un modulateur d'apoptose, et un procédé de fabrication d'un modulateur de l'expression du gène bbc3. La présente invention concerne enfin des composés identifiés par chacune des méthodes de l'invention, ainsi que des promoteurs du gène bbc3 et des séquences homologues.
Chittenden Thomas
Han Jia-Wen
Gowling Lafleur Henderson Llp
Immunogen Inc.
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