Bc200 rna, probes therefor and use thereof

Details Bc200 rna, probes therefor and use thereof Bc200 rna, probes therefor and use thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2163249

The 3'-end of BC200 RNA, commencing at nucleotide 159 has the sequence: UAAGCGUAAC UUCCCUCAAA GCAACAACCC CCCCCCCCCU UU 42, [SEQ ID NO 2]. Oligonucleotide probes in accordance with the invention are complementary to at least a portion of this sequences such that they bind specifically and selectively to human BC200 RNA. The probes are useful in determining the distribution of BC200 RNA in the body and as an indicator of neoplastic diseases in non-neuronal tissue.

L'extrémité -3' de l'ARN BC200, commençant au niveau du nucléotide 159, possède la séquence suivante: UAAGCGUAAC UUCCCUCAAA GCAACAACCC CCCCCCCCCU UU 42 [SEQ ID NO 2]. Les sondes d'oligonucléotides décrites par l'invention sont complémentaires à au moins une partie de ladite séquence, de sorte qu'elles se fixent spécifiquement et sélectivement à l'ARN BC200 chez l'homme. Ces sondes sont efficaces pour déterminer la répartition de l'ARN BC200 dans l'organisme et en tant qu'indicateur de maladies néoplasiques dans le tissu non neuronal.

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