Bcd tricyclic ergoline part-structure analogues

Details Bcd tricyclic ergoline part-structure analogues Bcd tricyclic ergoline part-structure analogues

C - Chemistry, Metallurgy

07

D

167/219, 167/227

C07D 471/04 (2006.01) C07D 215/20 (2006.01) C07D 215/233 (2006.01) C07D 215/42 (2006.01) C07D 215/54 (2006.01) C07D 491/10 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1307526

Abstract 7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydro- genated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquino- lines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydro- quinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.

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