Bci-2-like protein bim and methods of use thereof

Details Bci-2-like protein bim and methods of use thereof Bci-2-like protein bim and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2304124

The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as "Bim", and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

De manière générale, l'invention concerne de nouvelles molécules, capables notamment de moduler l'apoptose des cellules de mammifères, et des séquences génétiques codant pour lesdites molécules. Plus particulièrement, elle concerne un nouveau membre de la famille BCL-2 des protéines, dénommé ici "Bim", et des séquences génétiques codant pour ladite protéine. Les molécules de la présente invention sont utiles, par exemple, pour le traitement, le diagnostic et la production d'anticorps, ainsi que comme agent de criblage pour des agents thérapeutiques capables de moduler la mort physiologique ou la survie des cellules et/ou de moduler leur entrée dans le cycle cellulaire.

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