Bcl-g polypeptides, encoding nucleic acids and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2390662

The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl- G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a BcL-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.

La présente invention concerne des polypeptides Bcl-G et des acides nucléiques de codage. Les polypeptides Bcl-G contiennent Bcl-G¿L? et Bcl-G¿S?. Cette invention concerne également des Bcl-G de souris, des vecteurs contenant des acides nucléiques Bcl-G, des cellules hôtes contenant ces vecteurs, des acides nucléiques antisens Bcl-G et des compositions afférentes. De plus, cette invention concerne des oligonucléotides Bcl-G pouvant être utilisés dans l'hybridation ou l'amplification d'un acide nucléique BcL-G. Les anticorps spécifiques anti-Bcl-G sont également décrits dans cette invention. En outre, cette invention concerne des kits contenant des acides nucléiques Bcl-G ou des anticorps spécifiques Bcl-G. On peut utiliser ces kits et ces réactifs pour diagnostiquer le cancer, surveiller les réactions à la thérapie, ou prévoir le pronostic du patient cancéreux. Cette invention concerne également des procédés de modulation de l'apoptose utilisant des polypeptides Bcl-G, des acides nucléiques de codage, ou des composés qui modulent l'activité ou l'expression des polypeptides Bcl-G. On peut utiliser les procédés de modulation de l'apoptose pour traiter les maladies telles que le cancer.

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