Bcl-xy, a novel bcl-x isoform, and uses related thereto

Details Bcl-xy, a novel bcl-x isoform, and uses related thereto Bcl-xy, a novel bcl-x isoform, and uses related thereto

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262696

The present invention relates to BCL-x.gamma., a novel isoform of the BCL-x family of proteins which is predominantly expressed in T-lymphocytes and is associated with resistance to apoptosis. Both compositions of matter and methods are described which are useful in the treatment or prevention of immune system disorders.

L'invention se rapporte à la molécule BCL-x gamma , une nouvelle isoforme de la famille de protéines BCL-x, qui est exprimée de façon prépondérante dans les lymphocytes T et qui est associée à la résistance à l'apoptose. Des compositions de matières et des procédés utiles dans le traitement ou la prévention d'affections du système immunitaire sont également décrits.

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