Bcma polypeptides and uses thereof

Details Bcma polypeptides and uses thereof Bcma polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2590461

The present invent ion relates to BCMA polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids encoding said polypeptides, vectors comprising such nucleic acids and recombinant cells containing the same. The invention further discloses methods of producing such polypeptides, as well as methods and tools for detecting or dosing these polypeptides in any sample.

La présente invention concerne des variants polypeptidiques BCMA et leurs utilisations, en particulier pour le traitement thérapeutique ou prophylactique de sujets humains. Cette invention concerne également des acides nucléiques codant pour ces polypeptides, des vecteurs comprenant ces acides nucléiques et des cellules recombinantes contenant ces derniers. Ladite invention se rapporte en outre à des procédés de production desdits polypeptides ainsi qu'à des procédés et outils de détection ou de dosage de ces polypeptides dans un échantillon quelconque.

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