C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/28 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/04 (2006.01) C07K 14/82 (2006.01) C12N 5/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2213132
Compositions comprising or encoding one or more peptides that inhibit the Bcr- Abl oncoprotein and that bind to molecules involved in Bcr-Abl function are disclosed. The peptides and polypeptides inhibit the growth of, and induce cell death of, Philadelphia chromosome-positive leukemia cells expressing the Bcr-Abl oncoprotein. Methods for treating leukemias (e.g., CML, ALL and AML), including autologous bone marrow transplant therapy, using the peptide and polypeptide compositions of the invention are also provided.
Compositions comprenant ou codant un ou plusieurs peptides inhibant l'oncoprotéine Bcr-Abl et se liant aux molécules impliquées dans la fonction de Bcr-Abl. Les peptides et polypeptides inhibent la croissance et induisent la mort cellulaire des cellules de la leucémie positive à chromosome de Philadelphie exprimant l'oncoprotéine Bcr-Abl. Des méthodes de traitement de leucémies (telles que la leucémie myéloïde chronique, la leucémie aiguë lymphoblastique, la leucémie myélogène) dont la thérapie par transplantation autologue de la moelle osseuse, à l'aide des compositions peptidiques et polypeptidiques selon l'invention sont également décrites.
Arlinghaus Ralph B.
Berestein-Lopez Gabriel
Liu Jiaxin
Lu Dai
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
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