Bcrp/abcg2 inhibitor

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/04 (2006.01) A61K 31/277 (2006.01) A61K 31/34 (2006.01) A61K 31/381 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) A61K 31/47 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07C 255/37 (2006.01) C07D 307/56 (2006.01) C07D 333/26 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2602467

Disclosed is a breast cancer resistant protein (BCRP/ABCG2) inhibitor. A BCRP inhibitor comprising an acrylonitrile derivative represented by the general formula (1) or a salt thereof as the active ingredient: (1) (E or Z) wherein one of R1 and R2 represents a cyano group and the other represents a hydrogen atom; Ar1 represents a group selected from the groups represented by the formulae (2) to (4) below; and Ar2 represents an aromatic hydrocarbon group which has a fused ring optionally substituted by a halogen atom or a group selected from the groups represented by the formulae (5) to (15) below.

L'invention concerne un inhibiteur de la protéine de résistance au cancer du sein (BCRP/ABCG2). L'inhibiteur de BCRP comprend un dérivé d'acrylonitrile représenté par la formule générale (1) ou un de ses sels comme ingrédient actif : (1) (E ou Z) où un élément parmi R1 et R2 représente un groupe cyano et l'autre représente un atome d'hydrogène ; Ar1 représente un groupe choisi parmi les groupes représentés par les formules (2) à (4) ci-dessous ; et Ar2 représente un groupe hydrocarboné aromatique ayant un cycle fusionné éventuellement substitué par un atome d'halogène ou un groupe choisi parmi les groupes représentés par les formules (5) à (15) ci-dessous.

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