Bead bound combinatorial oligonucleoside phosphorothioate...

Details Bead bound combinatorial oligonucleoside phosphorothioate... Bead bound combinatorial oligonucleoside phosphorothioate...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C40B 40/06 (2006.01) C40B 50/14 (2006.01)

Patent

CA 2502610

The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA, or even PNAs.

La présente invention concerne une composition et des méthodes de fabrication et d'utilisation d'une banque combinatoire comprenant deux ou plusieurs billes, un aptamère d'acide nucléique unique étant fixé à chaque bille et comportant une séquence unique disposée sur celui-ci. Les aptamères de la banque peuvent être fixés par covalence auxdites billes, lesquelles peuvent être des billes de polystyrène. Ces aptamères peuvent comprendre des liaisons phosphorothioate, phosphorodithioate et/ou méthylphosphonate et peuvent être des ADN, des ARN ou même des APN monocaténaires ou bicaténaires.

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