Bead bound combinatorial oligonucleoside phosphorothioate...

Details Bead bound combinatorial oligonucleoside phosphorothioate... Bead bound combinatorial oligonucleoside phosphorothioate...

C - Chemistry, Metallurgy

40

B

C40B 30/04 (2006.01) C07K 1/22 (2006.01) C12Q 1/68 (2006.01) C40B 20/08 (2006.01) G01N 35/00 (2006.01) C40B 40/06 (2006.01) C40B 50/14 (2006.01)

Patent

CA 2749227

The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA or even PNAs.

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