Bendamustine cyclopolysaccharide compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/40 (2006.01) A61K 31/4184 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2753641

The present invention is directed to pharmaceutical compositions comprising: (a) bendamustine, (b) a charged cyclopolysaccharide, and (c) a stabilizing agent having a charge opposite to that of the cyclopolysaccharide. Such composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. Such compositions are suitable for injection or infusion into patients in need for treatment with bendamustine.

La présente invention porte sur des compositions pharmaceutiques comprenant : (a) de la bendamustine, (b) un cyclopolysaccharide chargé et (c) un agent stabilisant ayant une charge opposée à celle du cyclopolysaccharide. Une telle composition fournit une stabilité souhaitable de façon inattendue dans des environnements réactifs tels que le plasma, couplée à une activité anti-cancer souhaitable de façon inattendue. De telles compositions sont appropriées pour une injection ou une infusion dans des patients ayant besoin d'un traitement par de la bendamustine.

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