Bendamustine pharmaceutical compositions for lyophilisation

A - Human Necessities – 61 – K

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A61K 9/19 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2593582

The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized bendamustine. The pharmaceutical formulations can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases. Preferred solvent used in a pre- lyophilized composition of bendamustine is tertiary-butyl alcohol .

L'invention porte sur des formulations pharmaceutiques de bendamustine lyophilisée qui conviennent à des fins pharmaceutiques. Cette invention porte sur des procédés de fabrication de bendamustine lyophilisée. Ces formulations pharmaceutiques peuvent être utilisées dans le cadre de n'importe quelle maladie sensible aux traitements à base de bendamustine, telles les maladies néoplastiques.

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