Beneficial agent delivery system with membrane plug

Details Beneficial agent delivery system with membrane plug Beneficial agent delivery system with membrane plug

A - Human Necessities

61

K

A61K 9/52 (2006.01) A61K 9/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2316886

An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.

La présente invention concerne un système d'administration osmotique permettant l'administration contrôlée d'un agent bénéfique, lequel système comprend une capsule implantée contenant un agent bénéfique et un agent osmotique qui gonfle au contact de l'eau, entraînant la libération progressive de l'agent bénéfique. Le système d'administration osmotique comprend un obturateur membranaire qui peut être traversé par l'eau provenant de l'extérieur de la capsule mais qui empêche les compositions contenues à l'intérieur de la capsule de s'en échapper. On règle la vitesse d'administration de l'agent bénéfique depuis la capsule en variant le diamètre central de l'obturateur membranaire à l'intérieur d'un diamètre de capsule constant. L'obturateur membranaire présente une vitesse de perméabilité variable qui est fonction de la mesure dans laquelle il est comprimé par les parois de la capsule.

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