Benodiazepine spirohydantoin cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2519515

The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des composés antagonistes des récepteurs de CGRP (peptide dérivé du gène de la calcitonine) utilisés pour traiter ou prévenir des maladies dans lesquelles CGRP est impliqué, telles que les céphalées, les migraines et les céphalées vasculaires de Horton. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions pour prévenir ou traiter des maladies dans lesquelles CGRP est impliqué.

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