C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/58 (2006.01) A61K 31/15 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07C 271/60 (2006.01) C07D 209/48 (2006.01) C07D 213/74 (2006.01) C07D 231/12 (2006.01) C07D 233/61 (2006.01) C07D 239/34 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 303/12 (2006.01) C07D 303/36 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2102042
BENZ[e]INDENE DERIVATIVES A b s t r a c t The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the said benz[e]indene derivatives in the treatment of certain diseases and in the preparation of pharmaceutical compositions suitable for the treatment of said diseases. The new benz[e]indene derivatives according to the invention correspond to the general formula Image (I), wherein A represents a group of the formula alk-NR1R2, wherein alk represents a C2-7 alkylene group optionally carrying a hydroxy substituent, R1 and R2 are independently hydrogen, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl or C3-7 cycloalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered ring, option- ally comprising an oxygen atom or a further nitro- gen atom, which latter may carry a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl substituent which substituents may, in turn, bear a hydroxy or methoxy group or a halogen atom; or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group; or A represents pyrimidino, 2,3-epoxypropyl or a group of the formula -C(O)NHR, wherein R3 stands for C1-7 alkyl, C2-7 alkenyl or C3-8 cyclo- alkyl; and R denotes hydrogen or C1-7 alkyl, stereoisomers and optionally active isomers and the possible mixtures thereof, further acid addition salts and quaternary ammonium derivatives of these compounds.
Blasko Gabor
Budai Zoltan
Fekete Marton
Gacsalyi Istvan
Gigler Gabor
Egis Gyogyszergyar Rt.
Fetherstonhaugh & Co.
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