Benzamide and heteroarylamide as p2x7 receptor antagonists

Details Benzamide and heteroarylamide as p2x7 receptor antagonists Benzamide and heteroarylamide as p2x7 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 253/075 (2006.01) A61K 31/53 (2006.01) A61P 31/00 (2006.01) C07D 211/76 (2006.01) C07D 213/64 (2006.01) C07D 241/08 (2006.01) C07D 249/12 (2006.01) C07D 263/24 (2006.01) C07D 279/16 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2466724

The present invention relates to novel to P2X7 inhibitors of formula (I) and to processes for their preparation, intermediates useful in their preparation, pharmaceuti-cal compositions containing them, and their use in therapy. The active compounds of the present invention are potent inhibitors of P2X7 and as such are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

La présente invention concerne de nouveaux inhibiteurs du récepteur P2X7, représentés par la formule générale (I), ainsi que leurs procédés de préparation, des intermédiaires utiles pour leur préparation, des compositions pharmaceutiques contenant ces inhibiteurs et leur utilisation dans certaines thérapies. Les composés actifs de la présente invention sont de puissants inhibiteur du récepteur P2X7 et sont par conséquent utiles pour le traitement de l'inflammation, de l'arthrose, de la polyarthrite rhumatoïde, du cancer, de la reperfusion ou de l'ischémie dans le cas d'un accident vasculaire cérébral ou d'une crise cardiaque, de maladies auto-immunes ou d'autres troubles.

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