Benzamide compounds as apo b secretion inhibitors

Details Benzamide compounds as apo b secretion inhibitors Benzamide compounds as apo b secretion inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/56 (2006.01) C07D 213/73 (2006.01) C07D 213/81 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 277/40 (2006.01)

Patent

CA 2425097

The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl, lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q1 is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A1)m-(A2)n-(A4)k-; Z is direct bond, -CH2-, - NH- or -O-; and R is hydrogen or lower alkyl, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

La présente invention concerne des composés représentés par la formule (I). Dans cette formule, R¿1? et R¿2? sont chacun indépendamment alkyle inférieur, alcényle inférieur, acyle, amino, alcoxy inférieur, cycloalkyloxy inférieur, aryle, aryloxy, sulfooxy, mercapto, sulfo, hydrogène, halogène, nitro, cyano ou hydroxy, ou peuvent former une structure cyclique. Q?1¿ est N ou CH. L est un groupe hétérocyclique de 3 à 10 membres, saturé, éventuellement substitué. X est arylène ou hétéroarylène monocyclique éventuellement substitué. Y est -(A?1¿)¿m?-(A?2¿)¿n?-(A?4¿)¿k?-. Z est liaison directe, -CH2-, -NH- ou -O-. Enfin, R est hydrogène ou alkyle inférieur, ou l'un de ses sels. Les composés de la présente invention, qui sont des inhibiteurs de la sécrétion d'apolipoprotéine B (Apo B), conviennent comme médicament en prévention ou traitement d'affections ou d'états résultant de niveaux élevés d'ApoB circulant.

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