Benzamide compounds useful as histone deacetylase inhibitors

Details Benzamide compounds useful as histone deacetylase inhibitors Benzamide compounds useful as histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2625970

The invention concerns benzamide compounds of formula (I), wherein R1 is a C- linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4 cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).

L'invention concerne des composés de benzamide de formule (I), dans laquelle R1 est un cycle pyrazole lié à un atome de C qui est facultativement substitué par un ou plusieurs groupes sélectionnés entre un alkyle en C1-4, un cycloalkyle en C3-4, un alcoxy en C1-4 et un cycloalcoxy en C3-4 ; ou un sel ou une forme de promédicament acceptable du point de vue pharmaceutique de ceux-ci. L'invention concerne également des procédés pour la préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication d'un médicament destiné à être utilisé en tant qu'agent antiprolifératif dans la prévention ou le traitement de tumeurs ou d'autres affections prolifératives, lesquelles sont sensibles à l'inhibition des histone désacétylases (HDAC).

Affiliated with

Also associated with

Rating

Benzamide compounds useful as histone deacetylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzamide compounds useful as histone deacetylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzamide compounds useful as histone deacetylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1846357