C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/245, 167/268
C07D 317/68 (2006.01) A61K 31/165 (2006.01)
Patent
CA 1252794
Abstract It has surprisingly been found that benzamides of the formula Image I wherein R1 and R2 each independently sig- nify hydrogen, halogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, sulphamoyl, mono(lower alkyl)sulphamoyl or di(lower alkyl)sulphamoyl or R1 and R2 on adjacent carbon atoms together signify a methylene- dioxy group, with the proviso that R2 is different from hydrogen when R1 signifies bromine in the 3-position, and their pharmaceutically usable acid addition salts have interesting monoamine oxidase inhibiting properties with low toxicity and can accordingly be used for the treat- ment of depressive states and Parkinsonism. Those compounds of formula I in which R1 signifies halogen, cyano or tri- fluoromethyl in the para-position and R2 signifies hydrogen or R1 and R2 together signify 2,4-dichloro, 3,4-dichloro or 3,4-methylenedioxy are novel; these novel compounds can be manufactured according to methods known per se.
445296
Da Prada Mose
Joos Renato
Kyburz Emilio
Wyss Pierre C.
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited/hoffmann-La Roche Limitee
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