C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/02 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2085963
- 99 - Abstract of the Disclosure: Benzamide derivatives of the following formula (I): (I) Image Image [wherein R1: B, D: hydrogen atom, etc. E: pyridyl group, etc. n: integer from 0 to 2 R2: R3R4N- etc. (R3, R4: optionally substituted C6 - C12 aryl group, etc.) A: -?- ,-CH2-, -N=N-, -CH=N-, -N=CH-, CH=CH- or -CH2-CH2-]. - 100 - optical antipodes thereof or pharmaceutically acceptable salts thereof, show excellent PAF antagonism and are effective for therapy and prophylaxis of diseases caused by PAF (bronchial asthma, nephritis, shocks, cardiac infarction, cerebral hemorrhage, ulcer, DIC, autoimmune diseases, thrombosis, etc.).
Hayashi Yoshio
Kitamura Toshihito
Morita Shuji
Yamada Noboru
Yamamoto Akihiro
Kirby Eades Gale Baker
Mitsubishi Chemical Corporation
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