Benzamide derivatives and their use as cytokine derivatives

Details Benzamide derivatives and their use as cytokine derivatives Benzamide derivatives and their use as cytokine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) C07D 213/81 (2006.01) C07D 215/48 (2006.01) C07D 231/14 (2006.01) C07D 239/42 (2006.01) C07D 241/44 (2006.01) C07D 249/06 (2006.01) C07D 261/18 (2006.01) C07D 263/34 (2006.01) C07D 271/12 (2006.01) C07D 277/20 (2006.01) C07D 307/68 (2006.01) C07D 307/79 (2006.01) C07D 307/84 (2006.01) C07D 307/91 (2006.01) C07D 311/58 (2006.01) C07D 333/38 (2006.01) C07D 333/70 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 409/04 (2006.01) C07D 417/02 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2340454

The invention concerns amide derivatives of formula (I) wherein R3 is (1- 6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1- 6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

L'invention concerne des dérivés d'amide représentés par la formule I I dans laquelle R?3¿ représente alkyle C¿1?-C¿6? ou halogéno; m est 0-3, p est 0-2 et q est 0-4; chacun de R?1¿ et R?2¿ représente un groupe tel qu'hydroxy, halogéno, trifluorométhyle et cyano; R?4¿ représente un groupe basique tel qu'amino, alkylamino C¿1?-C¿6?, dialkylamino C¿1?-C¿6?, dialkylamino C¿1?-C¿6?- alkyle C¿1?-C¿6?, dialkylamino C¿1?-C¿6?-alkoxy C¿2?-C¿6?, hétéroaryle, hétéroaryloxy, hétéroaryle-alkoxy C¿1?-C¿6?, hétérocyclyle, hétérocyclyloxy et hétérocyclyl-alkoxy C¿1?-C¿6?; et Q?2¿ représente un groupe tel qu'hétéroaryle, hétéroaryloxy ou hétéroaryl-alkoxy C¿1?-C¿6? éventuellement substitué; ou ses sels acceptables sur le plan pharmaceutique ou esters pouvant être clivés in vivo; procédés servant à les préparer, compositions pharmaceutiques les contenant et leur utilisation pour traiter des maladies ou états pathologiques dans lesquels les cytokines jouent le rôle d'intermédiaire.

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