Benzamide derivatives and their use as vasopressin antagonists

Details Benzamide derivatives and their use as vasopressin antagonists Benzamide derivatives and their use as vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 295/185 (2006.01) A61K 31/16 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 235/42 (2006.01) C07C 237/42 (2006.01) C07C 237/44 (2006.01) C07C 243/28 (2006.01) C07C 255/54 (2006.01) C07C 271/16 (2006.01) C07C 271/22 (2006.01) C07C 271/48 (2006.01) C07C 275/16 (2006.01) C07C 279/08 (2006.01) C07C 279/24 (2006.01) C07D 207/34 (2006.01) C07D 209/48 (2006.01) C07D 211/16 (2006.01) C07D 211/46 (2006.01) C07D 211/

Patent

CA 2223869

This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc., and represented by general formula (I), wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is lower alkoxy, etc., R5 is hydrogen, etc., A is NH, etc., E is (a), etc., X is -CH=CH-, -CH=N-, or S, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.

La présente invention concerne d'une part des dérivés de type benzamide présentant notamment une activité antagoniste de la vasopressine et d'autre part des sels de ces dérivés admis en pharmacologie. L'invention concerne également des procédés de préparation de ces dérivés ou sels ainsi que des compositions à base de ces dérivés ou sels. Ces dérivés sont représentés par la formule générale (I) dans laquelle R?1¿ est aryle à substitution alcoxy inférieur éventuelle, R?2¿ est alkyle inférieur, R?3¿ est alcoxy inférieur, R?5¿ est hydrogène, A est NH, E est (a), X est -CH=CH-, -CH=N- ou S, et Y est CH ou N.

Affiliated with

Also associated with

Rating

Benzamide derivatives and their use as vasopressin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzamide derivatives and their use as vasopressin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzamide derivatives and their use as vasopressin antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1427885