Benzamide derivatives as thrombin inhibitors

Details Benzamide derivatives as thrombin inhibitors Benzamide derivatives as thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4409 (2006.01)

Patent

CA 2345997

There are provided according to the invention novel compounds of formula (I), wherein R1 represents C1-4alkyl or C3-8cycloalkyl, R2 represents C1-4alkyl or C3-4alkenyl, R3 represents hydrogen, C1-3alkyl or halogen, and R4 represents C1-6alkyl, processes for preparing them, pharmaceutical formulations containing them and their use in therapy particularly as thrombin inhibitors.

L'invention porte sur de nouveaux composés de formule (I), dans laquelle R?1¿ représente C¿1-4?alkyle ou C¿3-8?cycloalkyle, R?2¿ représente C¿1-4?alkyle ou C¿3-4?alcényle, R?3¿ représente hydrogène, C¿1-3?alkyle ou halogène, et R?4¿ représente C¿1-6?alkyle. L'invention porte également sur leurs procédés d'obtention, sur des préparations pharmaceutiques les contenant, et sur leurs indications thérapeutiques, notamment comme inhibiteurs de la thrombine.

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