Benzamide derivatives useful as histone deacetylase inhibitors

Details Benzamide derivatives useful as histone deacetylase inhibitors Benzamide derivatives useful as histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 211/34 (2006.01) C07D 213/74 (2006.01) C07D 215/12 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 239/42 (2006.01) C07D 241/20 (2006.01) C07D 251/18 (2006.01) C07D 277/24 (2006.01) C07D 277/30 (2006.01) C07D 295/14 (2006.01) C07D 295/155 (2006.01) C07D 307/54 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 409/04 (2006.01) C07D 417/06 (2006.01) C07D 4

Patent

CA 2480356

The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase.

L'invention concerne un composé de formule générale (I) dans laquelle le noyau A est hétérocyclyle; m vaut entre 0 et 4 et chaque R?1¿ est un groupe de type hydroxy, halo, trifluorométhyle et cyano; R?2¿ est halo et n vaut entre 0 et 2; et chaque R?4¿ est un groupe de type hydroxy, halo, trifluorométhyle et cyano; p vaut entre 0 et 4; et R?3¿ est amino ou hydroxy; ou des sels pharmaceutiquement acceptables ou un ester ou un amide hydrolysable in vivo dudit composé; des procédés de préparation associés; des compositions pharmaceutiques contenant ledit composé et l'utilisation de celui-ci dans le traitement de maladies ou d'états dont la médiation est assurée par l'histone déacetylase.

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