C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/12 (2006.01) A61K 31/4196 (2006.01) A61P 11/00 (2006.01) A61P 37/00 (2006.01) C07D 233/70 (2006.01)
Patent
CA 2511189
The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I) wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
La présente invention concerne des inhibiteurs benzamidiques du récepteur P2X¿7? de formule (I), dans laquelle R?1¿ à R?3¿ sont tels que définis dans la description. Les composés de l'invention sont utiles dans le traitement de troubles médiés par l'IL-1, y compris, entre autres, les maladies inflammatoires telles que l'ostéoarthrite et l'arthrite rhumatoïde, les allergies, l'asthme, la BPCO, le cancer, la reperfusion ou l'ischémie lors d'un AVC ou d'une crise cardiaque, les maladies auto-immunes et d'autres pathologies.
Dombroski Mark A.
Duplantier Allen J.
Subramanyam Chakrapani
Pfizer Products Inc.
Sim & Mcburney
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