Benzamide inhibitors of the p2x7 receptor

Details Benzamide inhibitors of the p2x7 receptor Benzamide inhibitors of the p2x7 receptor

C - Chemistry, Metallurgy

07

D

C07D 213/54 (2006.01) A61K 31/395 (2006.01) C07D 231/12 (2006.01) C07D 237/04 (2006.01) C07D 237/08 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2525437

The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R1 -R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

La présente invention se rapporte à des inhibiteurs benzamidiques du récepteur P2X¿7? répondant à la formule (I), dans laquelle R?1¿ à R?3¿ ont les définitions données dans la description. Les composés selon l'invention sont utilisables dans le traitement des troubles à médiation par IL-1, à savoir notamment mais non exclusivement les maladies inflammatoires telles que l'arthrose et l'arthrite rhumatoïde ; les allergies, l'asthme, la bronchopneumopathie chronique obstructive, les cancers, la reperfusion ou l'ischémie en cas d'accident vasculaire cérébral ou d'infarctus, les maladies auto-immunes et d'autres troubles.

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