C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/192 (2006.01) A61K 31/395 (2006.01) A61P 25/00 (2006.01) C07C 233/65 (2006.01) C07D 205/04 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 211/48 (2006.01) C07D 217/06 (2006.01) C07D 235/26 (2006.01) C07D 271/06 (2006.01) C07D 401/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2689282
In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Selon un aspect, la présente invention concerne des composés, comprenant des dérivés benzamides et des dérivés benzamides cycliques, qui sont utiles en tant que modulateurs positifs allostériques du récepteur de sous-type 5 du glutamate (mGluR5); des procédés synthétiques pour la fabrication des composés; des compositions pharmaceutiques comportant les composés; et des procédés de traitement de troubles neurologiques et psychiatriques associés au dysfonctionnement glutamatergique mettant en AEuvre les composés et les compositions. Cet abrégé est soumis afin de permettre une recherche générale dans ce domaine précis et ne doit pas être utilisé pour limiter la portée de la présente invention.
Conn P. Jeffrey
Jones Carrie K.
Lindsley Craig W.
Niswender Colleen M.
Rodriguez Alice L.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Vanderbilt University
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