Benzamide modulators of metabotropic glutamate receptors

Details Benzamide modulators of metabotropic glutamate receptors Benzamide modulators of metabotropic glutamate receptors

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07C 233/05 (2006.01) C07D 213/02 (2006.01)

Patent

CA 2519954

The present invention is directed to compounds which are allosteric modulators of metabotropic glutamate receptors, including the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

L'invention concerne des composés qui sont des modulateurs allostériques de récepteurs métabotropiques du glutamate, notamment le récepteur mGluR5, et sont utiles pour le traitement et la prévention de troubles neurologiques et psychiatriques associés à une dysfonction de glutamate et à des maladies dans lesquelles sont impliqués les récepteurs métabotropiques du glutamate. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et des compositions pour la prévention et pour le traitement de maladies dans lesquelles sont impliqués les récepteurs métabotropiques du glutamate.

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