Benzamide multidrug resistance reversing agents

Details Benzamide multidrug resistance reversing agents Benzamide multidrug resistance reversing agents

C - Chemistry, Metallurgy

07

C

C07C 237/44 (2006.01) A61K 31/165 (2006.01) C07C 323/12 (2006.01) C07C 323/63 (2006.01)

Patent

CA 2074061

CT-2153 ABSTRACT Benzamides of formula I Image I wherein p is 1 to 3; R1 is hydrogen or an acyl group R6CO-, in which R6 is C-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl, aryl or radical of the formula Image ; R3 is hydrogen or W, where W is a radical of the formula Image CT-2153 in which R7 and R8 each are independently CF3, H or -NO2, provided at least either R7 or R3 is -NO2; R2 is W or a radical of the formula Image in which X is hydrogen or a halogen, k is 2 or 3, and m is 0 or 1; and R4 and R5 each are independently C1-6 alkyl are useful for the reversal of multidrug resistance to cancer drugs.

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