C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 313/04 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/265 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) A61K 31/343 (2006.01) A61K 45/06 (2006.01) A61P 37/06 (2006.01) C07C 233/65 (2006.01) C07C 235/60 (2006.01) C07C 271/02 (2006.01) C07C 271/20 (2006.01) C07D 307/78 (2006.01) C07D 307/79 (2006.01)
Patent
CA 2348446
This invention relates to benzamide potassium channel inhibitors of general structural formula (I). The compounds of this invention are useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and related afflictions, diseases and illnesses, and cardiac arrhythmias. Also within the scope of this invention are pharmaceutical formulations comprising a compound of formula (I) and a pharmaceutical carrier, as well as pharmaceutical formulations comprising a compound of formula (I), one or more immunosuppressive compounds and a pharmaceutical carrier.
L'invention concerne des inhibiteurs benzamidiques de canaux potassiques de formule générale structurelle (I). Les composés de cette invention sont utilisés pour traiter les maladies auto-immunes et prévenir le rejet de transplantations d'organes et les troubles et maladies y relatifs, ainsi que l'arythmie cardiaque. Cette invention concerne également des formulations pharmaceutiques renfermant un composé de formule (I) et un excipient pharmaceutique, ainsi que des compositions pharmaceutiques contenant un composé de formule (I), un ou plusieurs composés immunosuppresseurs, et un excipient pharmaceutique.
Baker Robert K.
Bao Jianming
Claiborne Christopher F.
Claremon David A.
Kayser Frank
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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