C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/18 (2006.01) A61K 31/155 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) C07C 257/18 (2006.01) C07C 323/63 (2006.01) C07D 235/18 (2006.01) C07D 307/54 (2006.01) C07D 307/68 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2237650
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.
La présente invention concerne une thérapie contre la pneumonie par Pneumocystis carinii chez un sujet justifiant d'une telle thérapie. La thérapie consiste en l'administration par voie orale au sujet d'un bis-benzamidoxime, ou de l'un de ses sels pharmaceutiquement acceptables, qui est réduit chez le sujet de façon à produire une benzamidine dotée d'activité anti-P. carinii. Sous une autre réalisation, la thérapie de la présente invention peut consister en l'administration par voie intraveineuse au sujet d'un composé actif tel que celui de l'invention. L'invention concerne également des formulations pharmaceutiques et des composés actifs convenant pour la mise en oeuvre de la présente invention.
Boykin David Withers
Hall James Edwin
Tidwell Richard Ray
Georgia State University
Sim & Mcburney
The University Of North Carolina At Chapel Hill
University Of North Carolina At Chapel Hill
LandOfFree
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