Benzazepin-2-ones

Details Benzazepin-2-ones Benzazepin-2-ones

C - Chemistry, Metallurgy

07

D

260/241

C07D 223/16 (2006.01) C07D 491/056 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1196636

Benzazepin-2-ones Abstract of the disclosure The invention concerns angiotensin-converting enzyme (ACE) inhibitors of the formula I (I) Image wherein RA and RB are radicals of the formula Image and Image , respectively, in which Ro is carboxy or a functionally modified carboxy; R1 is hydrogen, lower alkyl, amino(lower) alkyl, aryl, aryl (lower) alkyl, cycloalkyl or cycloalkyl (lower) alkyl; R2 is hydrogen or lower alkyl, R3 and R4, each independently, represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyloxy, hydroxy, halogen, tri- fluoromethyl, or R3 and R4 taken together represent lower alkylene- dioxy; R5 is hydrogen or lower alkyl, and X represents oxo, two hydrogens, or one hydroxy together with one hydrogen; and wherein the carbocyclic ring may also be hexahydro or 6,7,8,9-tetrahydro; salts and complexes thereof; and stereoisomers of all these compounds. They are prepared, for example, by reducing a compound corresponding to the formula I, having an additional double bond located at the carbon atom in 3-position.

409019

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