Benzazepine and benzazepinone derivatives

Details Benzazepine and benzazepinone derivatives Benzazepine and benzazepinone derivatives

C - Chemistry, Metallurgy

07

D

260/239.7

C07D 401/06 (2006.01) C07D 223/16 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1321194

ABSTRACT This invention relates to a novel compound of formula I Image (I) (wherein A represents a -CH2-CH2-, -CH=CH-, -CH2-CO- or -NH-CO- group, and * * B represents a methylene, carbonyl or thiocarbonyl group,or Image A represents a -CO-CO- or group and B represents a methylene group, the mark * signifying that the carbon or nitrogen atom so marked is bonded to the phenyl ring; E represents a straight-chained alkylene group with 1 to 3 carbon atoms optionally substituted by an alkyl group with 1 to 3 carbon atoms; G represents a group G1G2 optionally substituted by an alkyl group with 1 to 3 carbon atoms and wherein G1 represents a straight-chained alkylene group with 1 to 5 carbon atoms and G2, which is adjacent to the phenyl ring, represents a bond linking G1 to the phenyl ring or, where G1 represents a straight-claimed alkylene group with 2 to 4 carbon atoms, an oxygen or sulphur atom or an imino, methylimino, sulphinyl or sulphonyl group; R1 represents a hydrogen or halogen atom or, a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxy, alkoxy or phenylalkoxy group, wherein any alkyl moiety in R1 contains from 1 to 3 carbon atoms, and R2 represents a hydrogen or halogen atom, or a hydroxy, alkoxy, phenylalkoxy or alkyl group, wherein any alkyl moiety in R2 contains from 1 to 3 carbon atoms, or R1 and R2 together represent an alkylenedioxy group with 1 or 2 carbon atoms; R3 represents a hydrogen or halogen atom, or an alkyl group with 1 to 3 carbon atoms, or an alkoxy group with 1 to 3 carbon atoms, or a hydroxy, nitro, cyano or trifluoromethyl group, and R4 represents a hydrogen atom, or an amino group, or an alkoxy, alkanesulphonyloxy, alkylamino or dialkylamino group with 1 to 3 carbon atoms in the or each alkyl moiety or an alkanoylamino group with 2 or 3 carbon atoms in the alkanoyl moiety; or R3 and R4 together represent an alkylenedioxy group with 1 or 2 carbon atoms; R5 represents a hydrogen or halogen atom, or a hydroxy group, or an alkyl or alkoxy group with 1 to 3 carbon atoms in the alkyl moiety; m represents the number 1, 2, 3, 4 or 5, and n represents the number 0, 1 or 2, with the proviso that the sum of n and m is 3, 4 or 5); the enantiomers, diastereomers and acid addition salts thereof.

523713

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