Benzazepine derivatives

Details Benzazepine derivatives Benzazepine derivatives

C - Chemistry, Metallurgy

07

D

260/241.4

C07D 223/16 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01)

Patent

CA 1294617

ABSTRACT The d-cis enantiomer of a compound having the formula: Image wherein R and R1 are each hydrogen or alkyl, R is hydrogen and R1 is alkenyl, alkynyl, aryl, heter- oaryl or cycloalkyl, or R and R1 together with the carbon atom to which they are attached are cycloalkyl; R4 and R5 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, ar- ylalkyl, hydroxy, alkanoyloxy, -O-?-NX1X2, di- fluoromethoxy, trifluoromethyl, -NX3X4, -S(O)malkyl or -S(O)maryl; m is 0, 1 or 2; X1 and X2 are each independently hydrogen, alkyl, aryl or heteroaryl, or X1 and X2 together with the nitrogen atom to which they are attached are a nitrogen containing heteroaryl; X3 and X4 are each independently hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroarylcarbonyl or carbamoyl. These compounds are useful as in- termediates for the preparation of compounds of the formula: Image and pharmaceutically acceptable salts thereof, which are themselves useful in that they possess vasodilating activity.

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