Benzazepine derivatives

Details Benzazepine derivatives Benzazepine derivatives

C - Chemistry, Metallurgy

07

D

167/209, 260/239

C07D 223/16 (2006.01) C07C 59/64 (2006.01) C07D 243/04 (2006.01) C07D 243/10 (2006.01) C07D 405/12 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1247612

Abstract Benzazepine derivatives This invention relates to new benzazepine derivatives of formula I Image (I) (wherein A represents a -CH2CH2- or -CH=CH-group; R1 represents a hydrogen, chlorine or bromine atom, an amino or hydroxy group, or an alkyl, alkylamino, dialkylamino, acylamino, alkoxy or phenylalkoxy group in which the or each alkyl moiety may contain from 1 to 3 carbon atoms, R2 represents a hydrogen, chlorine or bromine atom, a hydroxy group, or an alkyl, alkoxy or phenylalkoxy group in which the alkyl moiety may contain from 1 to 3 carbon atoms, or R1 and R2 together represent an alkylenedioxy group with 1 or 2 carbon atoms; R3 represents a hydrogen, chlorine or bromine atom or an alkoxy group, containing from 1 to 3 carbon atoms; R4 represents a hydrogen atom, a benzyl group, an alkyl group containing from 1 to 3 carbon atoms or an alkenyl group containing from 3 to 5 carbon atoms; R5 represents a hydrogen or halogen atom, or an alkyl or alkoxy group with 1 to 3 carbon atoms, R6 represents a hydrogen atom or an alkyl or alkoxy group with 1 to 3 carbon atoms, or R5 and R6 together represent an alkylenedioxy group with 1 or 2 carbon atoms; X represents an imino group optionally substituted by a benzyl group or by an alkyl group with 1 to 3 carbon atoms, or an oxygen or sulphur atom or a sulfinyl or sulfonyl group; Y represents an imino group optionally substituted by a benzyl group or by an alkyl group with 1 to 3 carbon atoms, or a methylene or carbonyl group; n represents the number 2, 3 or 4; and m represents the number 2, 3 or 4) and acid addition salts thereof. The compounds have valuable pharmacological properties, particularly the effect of lowering heart rate and reducing the O2 requirement of the heart.

481560

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