Benzazepine derivatives

Details Benzazepine derivatives Benzazepine derivatives

C - Chemistry, Metallurgy

07

D

260/241.15

C07D 487/04 (2006.01) C07C 29/147 (2006.01) C07C 45/30 (2006.01) C07C 51/347 (2006.01) C07D 207/34 (2006.01) C07D 209/94 (2006.01)

Patent

CA 1202970

ABSTRACT Compounds of the formula Image I wherein R1 and R3 are hydrogen, lower alkyl, hydroxy, lower alkoxy or acyloxy and R2 and R4 are hydrogen or R1 and R2 and/or R3 and R4 taken together are oxo groups with the proviso that at least one oxo group is present; R is hydrogen, lower alkyl, C2 to C7 carboxylic acids and the esters and amides thereof, hydroxy C2 to C7 alkyl, amino C2 to C7 alkyl or mono- or di-lower alkyl amino C2 to C7 alkyl; R5 is halogen having an atomic number not greater than 35 or hydrogen; and R6 is halogen having an atomic number not greater than 35 with the proviso that when R1 or R3 is hydroxy, lower alkoxy or acyloxy, then R is lower alkyl or hydrogen and the N-oxides and the pharmaceutically acceptable salts thereof exhibit activity as sedative and anxiolytic agents.

428213

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