C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/241.15
C07D 487/04 (2006.01) C07C 29/147 (2006.01) C07C 47/55 (2006.01) C07C 63/72 (2006.01) C07D 231/12 (2006.01) C07D 231/14 (2006.01)
Patent
CA 1173031
RAN 4008/320 Abstract There are presented pyrazolobenzazepines of the formulas Image and Image wherein R1 is hydrogen or lower alkyl; R2 and R3 are hydrogen, lower alkyl, hydroxy C2 to C7 alkyl, C2 to C7 carboxylic acid esters and amides or the group COR11 wherein R11 is alkoxy, amino or mono- lower alkyl amino; R6 is nitro or halo having an atomic number not greater than 35, R5 is hydrogen or halo having an atomic number not greater than 35 and n is 0 or 1 and the pharmaceutically acceptable salts thereof. These pyrazolobenzazepines are useful as anxiolytic and sedative aqents. Also provided are processes and intermediates in the production of the above pyrazolobenzazepines.
383116
Field George F.
Fryer Rodney I.
Trybulski Eugene J.
Walser Armin
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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