Benzazepine derivatives as alpha-v integrin receptor...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 267/02 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) C07D 243/12 (2006.01) C07D 491/00 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2358855

The present invention relates to benzazepine derivatives and their use as alpha-V integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaVbeta3, alphaVbeta5, and/or alphaVbeta6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.

Cette invention concerne des dérivés de la benzazépine et leur utilisation en tant qu'antagonistes des récepteurs d'l'intégrine alpha-V. Plus particulièrement, les composés selon l'invention sont des antagonistes des récepteurs alphaVbeta3, alphaVbeta5, et/ou alphaVbeta6 d'intégrine. Ils servent à inhiber la résorption osseuse, à traiter et à prévenir l'ostéoporoses, à favoriser la cicatrisation des blessures, à inhiber la resténose vasculaire, la rétinophatie diabétique, a dégénérescence maculaire, l'angiogenèse, l'athérosclérose, les inflammations, les maladies virales, et la croissance des tumeurs et des métastases.

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