A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 223/16 (2006.01)
Patent
CA 2543287
The present invention relates to novel benzazepine derivatives of the following formula: (I) wherein R1, R2, R3, R4 and R5, X, X~, Y and Y~ are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
La présente invention porte sur de nouveaux dérivés de benzazépine de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿, X, X', Y et Y' sont tels que définis dans le descriptif et les revendications, sur leurs procédés de préparation, sur des compositions pharmaceutiques contenant ces dérivés et sur leur utilisation dans la préparation de médicaments utiles dans la prévention et le traitement de maladies dans lesquelles l'inhibition sélective de l'activité de l'oxydase B de la monoamine joue un rôle ou est impliquée.
Jolidon Synese
Rodriguez Sarmiento Rosa Maria
Thomas Andrew William
Wostl Wolfgang
Wyler Rene
Borden Ladner Gervais Llp
F.hoffmann-La Roche Ag
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