Benzazepine derivatives as vasopressin antagonists

Details Benzazepine derivatives as vasopressin antagonists Benzazepine derivatives as vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2066104

The present invention is directed to novel benzoheterocyclic compounds of the formula: (see formula I) wherein R1 is H, halogen, OH, etc.; R2 is H, alkyl, halogen or alkoxy; R3 is phenyl-alkanoylamino, or (see formula II); R4 is H, -NR6R7, alkenyloxy, HO-alkyl, -O-CO-A-NR8R9, etc .; R5 is H, OH, etc., or a salt thereof. The compounds of the present invention have excellent vasopressin antagonistic activities and are useful as vasodilators; hypotensive agents, water diuretics, platelet agglutination inhibitors. The invention is also directed to a vasopressin antagonistic composition containing the novel benzoheterocyclic compounds as the active ingredient.

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