A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2362273
The invention relates to the use of benzazepine-N ethanoic acid derivatives, containing an oxo group bonded to the nitrogen atom in the .alpha.-position and which are substituted by a 1-(carboxy alkyl)-cyclopentyl-carbonyl amino radical in position 3. It also relates to the use of the salts and unstable esters of these derivatives in the treatment of hypertension, particularly to the treatment of certain types of secondary hypertension in large mammals and humans and to the production of suitable medicaments for this treatment. The origins of the hypertension which should be treated can vary greatly. The invention relates specifically to those types of secondary hypertension which may arise as a result of various non-cardiac diseases.
Cette invention concerne l'utilisation de dérivés d'acide N-benzazépine acétique comprenant un groupe oxy relié à l'atome d'azote en position alpha et étant substitués par un reste 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino en position 3. Elle concerne également l'utilisation des sels et des esters biologiquement instables de ces dérivés dans le traitement de l'hypertension artérielle, notamment de certaines formes d'hypertension artérielle secondaire, chez les mammifères et en particulier chez l'homme, ainsi que la production de médicaments adaptés à ce traitement. Les origines de l'hypertension artérielle à traiter peuvent ici être des plus diverses. Cette invention concerne notamment le traitement des formes de tension artérielle secondaire pouvant résulter de différentes maladies non cardiaques.
Thormahlen Dirk
Waldeck Harald
Wilkins Martin R.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Solvay Pharmaceuticals Gmbh
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