Benzazole derivatives, compositions, and methods of use as...

Details Benzazole derivatives, compositions, and methods of use as... Benzazole derivatives, compositions, and methods of use as...

C - Chemistry, Metallurgy

07

D

C07D 235/30 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/4725 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2600570

The present invention is directed to benzazole compounds that inhibit .beta.- site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.

La présente invention concerne des composés de benzazole qui inhibent l'enzyme intervenant dans le clivage de la protéine précurseur bêta-amyloïde (BACE), et peuvent être utiles dans le traitement ou la prévention de maladies dans lesquelles BACE est impliquée, telles que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, et l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles BACE est impliquée.

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