Benzcycloamide derivatives

Details Benzcycloamide derivatives Benzcycloamide derivatives

C - Chemistry, Metallurgy

07

D

260/283, 260/289

C07D 209/34 (2006.01) C07D 215/22 (2006.01)

Patent

CA 1064036

ABSTRACT OF THE DISCLOSURE Novel benzcycloamide derivatives represented by the general formula, Image (I) wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl or aralkyl; B is -CH2-, -CH2-CH2- or -CH=CH-; A is Image (wherein R2 and R3 may be the same or different and are respectively hydrogen or C1-4 alkyl) or -CH=CH-; R4 is -OR5 (wherein R5 is hydrogen, C1-8 alkyl, cycloalkyl or aralkyl) or Image (wherein R6 and R7 may be the same or different and are respec- tively hydrogen, C1-4 alkyl or aralkyl or may form together with the nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a nitrogen, oxygen or sulfur atom); and m and n each are zero or a positive integer and m + n is no more than 11. The benzcycloamide derivatives represented by the above-mentioned general formula (I) have ex- cellent effects of inhibiting platelet aggregation and are useful as preventives for thrombosis and embolism.

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