Benzene derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 233/64 (2006.01) A61K 31/195 (2006.01) A61K 31/415 (2006.01) C07C 275/34 (2006.01) C07C 275/42 (2006.01) C07D 233/54 (2006.01) C07D 307/89 (2006.01)

Patent

CA 2115915

ABSTRACT The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient. The benzene derivative according to the present invention is represented by the following general formula (I): Image (I) [wherein R1 represents a carboxyl group which may be protected or a group represented by the formula: - 44 - Image (wherein R5 represents a lower alkyl group or a hydroxyalkyl group and R6 represents a hydrogen atom or a hydroxyl group); R2 represents a hydrogen atom, a lower alkyl group or the like; R3 and R4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6.]. - 45 -

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