C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 309/51 (2006.01) A61K 31/185 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01)
Patent
CA 2421581
The present invention relates to trimesic acid amides, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, and processes for their preparation. Specifically, this invention relates to means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that active the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, as well as processes for preparation of the compounds. As such, the invention also concerns methods or uses of the compounds for the treatment of animals with hyperglycemia, especially for the treatment of type 2 diabetes.
La présente invention concerne des composés chimiques, des compositions pharmaceutiques comprenant ces composés, des utilisations de ces composés et compositions, et des procédés permettant leur élaboration. L'invention concerne en l'espèce des moyens permettant de renforcer l'assimilation insulinodépendante du glucose. L'invention concerne plus particulièrement, d'une part des composés et des compositions pharmaceutiques qui activent la kinase du récepteur de l'insuline, ce qui aboutit à une augmentation de la sensibilité à l'insuline et à une augmentation de l'assimilation du glucose, et d'autre part des procédés permettant l'élaboration de ces composés. En tant que telle, l'invention concerne également des procédés ou des utilisations de composés permettant le traitement d'animaux souffrant d'hyperglycémie, et plus particulièrement pour le traitement du diabète de type 2.
Cairns Nicholas
Manchem Prasad V. V. S. V.
Robinson Louise
Schow Steven R.
Dennison Associates
Telik Inc.
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