Benzenealkanoic acids for cardiovascular diseases

Details Benzenealkanoic acids for cardiovascular diseases Benzenealkanoic acids for cardiovascular diseases

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 229/34 (2006.01) C07C 233/11 (2006.01) C07C 233/63 (2006.01) C07C 235/34 (2006.01) C07C 235/78 (2006.01) C07C 317/32 (2006.01) C07C 317/48 (2006.01) C07D 213/71 (2006.01) C07D 307/64 (2006.01) C07D 333/34 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2145296

Compounds of formula (I) wherein R1, R2, R3 and R4 are each H or C1-C4 alkyl; R5 is (CH2)m NHSO2R6 or (CH)m NHCOR6; R6 is C1-C6 alkyl, C3-C6 cycloalkyl optionally substituted by aryl, aryl or heteroaryl; R7 is H, C1-C4 alkyl, C1-C4 alkoxy, halo, CF3, OCF3, CN, CONH2, or S(O)n(C1-C4 alkyl); X is CH2, CHCH3, CH(OH), C(OH)CH3, C=CH2, CO or O; m is 0 or 1 and n is 0, 1 or 2, and their pharmaceutically acceptable salts and biolabile esters, are antagonists of thromboxane A2 of utility, particularly in combination with a thromboxane synthetase inhibitor, in the treatment of athero- sclerosis and unstable angina and for prevention of reocclusion after percutaneous transluminal angioplasty.

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