Benzenesulfonamide derivative and process for preparing thereof

Details Benzenesulfonamide derivative and process for preparing thereof Benzenesulfonamide derivative and process for preparing thereof

C - Chemistry, Metallurgy

07

D

C07D 403/00 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 239/46 (2006.01) C07D 239/69 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/14 (2006.01) C07D 413/00 (2006.01) C07D 413/14 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2137953

The present invention is directed to a benzenesulfonamide derivative of the formula [I]: (see formula I) wherein Ring A and Ring B are the same or different and each represent a substituted or unsubstituted benzene ring, Q is a single bond or a group of the formula: -O-, -S-, -SO-, -SO2- or -CH2-, Y is a group of the formula: -O-, -S- or - NH-, Alk is lower alkylene group or lower alkenylene group, Z is a single bond or a group of the formula: -O-, or -NH-, R is a substituted or unsubstituted aromatic heterocyclic or aryl group, R1 is a hydrogen atom, trifluoromethyl group, substituted or unsubstituted lower alkyl group, substituted or unsubstituted lower alkenyl group, mono- or di-lower alkylamino group, substituted or unsubstituted lower alkylthio group, substituted or unsubstituted lower alkoxy group, substituted or unsubstituted lower alkynyl group, aromatic heterocyclic group, substituted or unsubstituted aliphatic heterocyclic group or aryl group, provided that when Z is a single bond, R is a substituted or unsubstituted aromatic heterocyclic group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same. The compounds of the present invention having endothelin antagonistic activity and are useful in the prophylaxis or treatment of various diseases caused by endothelin.

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