C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/08 (2006.01) A61K 31/55 (2006.01) A61P 3/00 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2759494
The present invention relates to novel benzenesulfonanilide compounds of the Formulae (I) and (I') and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. (I) (I') F wherein R1 is hydrogen or methyl; R2 is hydrogen or methyl and is positioned vicinal to the radical R1; R3 hydrogen, C1-C3 alkyl, halogen, C1-C3 alkoxy, fluorinated C1-C3 alkyl or fluorinated C1-C3 alkoxy; R4 is hydrogen, C1-C4 alkyl, C3-C4 cycloalkyl, C3-C4 cycloalkylmethyl or fluorinated C1-C4 alkyl; R5 is hydrogen, fluorine, chlorine, C1-C4 alkyl, fluorinated C1-C4 alkyl, C1-C4 alkoxy or fluorinated C1-C4 alkoxy; and R6 is hydrogen, fluorine or chlorine.
L'invention porte sur de nouveaux composés de benzenesulfonanilide de formules (l) et (l'), sur des sels acidifiants physiologiquement tolérés et leurs oxydes de N. Ces composés dotées de propriétés thérapeutiques appréciables sont particulièrement adaptés au traitement de troubles répondant à la modulation du récepteur 5-HT6 de la sérotonine. Dans les formules (l) et (l'), R1 est hydrogène ou méthyle; R2 est hydrogène ou méthyle et est placé à côté du radical R1; R3 est hydrogène, C1-C3 alkyle, halogène, C1-C3 alkoxy, C1-C3 alkyle fluoré ou C1-C3 alkoxy fluoré; R4 est hydrogène, C1-C4 alkyle, C3-C4 cycloalkyle, C3-C4 cycloalkylméthyle ou C1-C4 alkyle fluoré; R5 est hydrogène, fluor, chlore, C1-C4 alkyle, C1-C4 alkyle fluoré, C1-C4 alkoxy ou C1-C4 alkoxy fluoré; et R6 est hydrogène, fluor ou chlore.
Backfisch Gisela
Bespalov Anton
Delzer Juergen
Drescher Karla
Haupt Andreas
Abbott Gmbh & Co. Kg.
Torys Llp
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